August 2014 Vol. 2 No.8

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Adelodun AO

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Original Research Article

A Chemotherapeutic Evaluation of Plant Extracts on Liver and Intestine of Mice: A Multivariate Regression Approach

Dr. O. A. Adelodun

Institute of Education, Obafemi Awolowo University, Ile-Ife. Nigeria

E-mail: segunadelodun@yahoo.com; adelodun@oauife.edu.ng

Accepted August 18, 2014

Abstract

Mice infected with 50 cercariae of Schistosoma mansoni in unequal group sizes are challenged with some doses of Zingiber officinale extracts, Cremophore and Praziquantel. Data are available for the number of male and female parasites, weights of liver and intestine, and egg per gramme liver and intestine tissues. Using an analysis of covariance model, the effects of the extracts and compound on intestine are predicted. The findings reveal, with the aid of likelihood-ratio statistic, a marked improvement in the precision of the estimates of the effects on intestine when the liver is taken into consideration.

Keywords: Shistosomiasis, Multivariate Regression, Likelihood-Ratio Statistics