
May
2023 Vol. 11 No.5
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Merit Research Journal of Medicine and Medical
Sciences (ISSN: 2354-323X) Vol. 11(5) pp. 157-163,
May, 2023
Copyright © 2023 Author(s) retain the copyright
of this article
DOI: 10.5281/zenodo.7974828 |
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Original Research Article
Assessment of Lead and Cadmium Concentration
in Liver and Kidney of Sprague Dawley Rats Exposed to Cultured
Vernonia amygdalina Leaves |
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Adjouavi Yvette DEGUENON1*, Bernadin Manou
ELEGBEDE2, Martin Pépin AINA1 |
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1National Water
Institute/Laboratory of Science of Water and Environmental
Engineering/University of Abomey-Calavi (UAC)
2National Water Institute/Laboratory of Water and
Environnemental Sciences and Techniques (LWEST)/University of
Abomey-Calavi (UAC)
*Corresponding Author’s E-mail: deguenonyvette01@gmail.com
Tel.: 00229 97644363
Received: 27 April 2023 I Accepted:
24 May 2023
I Published: 26 May 2023 I Article ID:
MRJMMS23020
Copyright © 2023 Author(s) retain the
copyright of this article.
This article is published under the terms of the
Creative Commons Attribution
License 4.0. |
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Abstract |
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Lead and cadmium
are among the heavy metals whose presence is feared because of
their toxicity. They enter the food chain by consuming plants
harvested from contaminated sites. In this study, we subjected
Sprague Dwaley rats to a 14-day chronic exposure to extracts of
Vernonia amygdalina leaves contaminated with different
concentrations of lead and cadmium solutions. The rats were
sacrificed and the liver and kidneys organs were removed. All
the samples were determined by flame atomic absorption
spectrophotometry. The results showed that the concentrations
contained in the administered extracts are 0.26ppm; 3.662ppm;
4.878ppm; 5.47ppm for lead on the one hand and 0.046ppm;
1.773ppm; 6.26ppm; 30.55ppm for cadmium on the other hand. Rats
in the control lot received distilled water. The different
bioaccumulated concentrations in the kidneys are in the order of
0.02ppm; 0.06ppm; 0.17ppm; 0.28ppm; 0.59ppm for lead and
0.06ppm; 0.06ppm; 0.51ppm; 0.64ppm; 0.78ppm for cadmium. In the
liver the following concentrations were accumulated 0.02ppm;
0.06ppm; 0.22ppm; 0.24ppm; 0.42ppm for lead and 0.04ppm;
0.10ppm; 0.15ppm; 0.35ppm; 0.45ppm for cadmium. Considering a
longer exposure period, the bioaccumulated concentrations will
be higher because circulating concentrations have not been
measured. The bioaccumulative nature of these metals in the
liver and kidney is important in assessing the risks associated
with the consumption of products contaminated with lead and
cadmium.
Keywords: Bioaccumulation, Plomb, Cadmium
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