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May 2023 Vol. 11 No.5
 

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Deguenon AY
Aina MP

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Merit Research Journal of Medicine and Medical Sciences (ISSN: 2354-323X) Vol. 11(5) pp. 157-163, May, 2023 

Copyright © 2023 Author(s) retain the copyright of this article
DOI: 10.5281/zenodo.7974828

Original Research Article

Assessment of Lead and Cadmium Concentration in Liver and Kidney of Sprague Dawley Rats Exposed to Cultured Vernonia amygdalina Leaves

 
 
 

Adjouavi Yvette DEGUENON1*, Bernadin Manou ELEGBEDE2, Martin Pépin AINA1

 

1National Water Institute/Laboratory of Science of Water and Environmental Engineering/University of Abomey-Calavi (UAC)
2National Water Institute/Laboratory of Water and Environnemental Sciences and Techniques (LWEST)/University of Abomey-Calavi (UAC)

*Corresponding Author’s E-mail: deguenonyvette01@gmail.com
Tel.: 00229 97644363

Received: 27 April 2023  I  Accepted: 24 May 2023  I  Published: 26 May 2023  I  Article ID: MRJMMS23020
Copyright © 2023 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

 

Abstract

 

Lead and cadmium are among the heavy metals whose presence is feared because of their toxicity. They enter the food chain by consuming plants harvested from contaminated sites. In this study, we subjected Sprague Dwaley rats to a 14-day chronic exposure to extracts of Vernonia amygdalina leaves contaminated with different concentrations of lead and cadmium solutions. The rats were sacrificed and the liver and kidneys organs were removed. All the samples were determined by flame atomic absorption spectrophotometry. The results showed that the concentrations contained in the administered extracts are 0.26ppm; 3.662ppm; 4.878ppm; 5.47ppm for lead on the one hand and 0.046ppm; 1.773ppm; 6.26ppm; 30.55ppm for cadmium on the other hand. Rats in the control lot received distilled water. The different bioaccumulated concentrations in the kidneys are in the order of 0.02ppm; 0.06ppm; 0.17ppm; 0.28ppm; 0.59ppm for lead and 0.06ppm; 0.06ppm; 0.51ppm; 0.64ppm; 0.78ppm for cadmium. In the liver the following concentrations were accumulated 0.02ppm; 0.06ppm; 0.22ppm; 0.24ppm; 0.42ppm for lead and 0.04ppm; 0.10ppm; 0.15ppm; 0.35ppm; 0.45ppm for cadmium. Considering a longer exposure period, the bioaccumulated concentrations will be higher because circulating concentrations have not been measured. The bioaccumulative nature of these metals in the liver and kidney is important in assessing the risks associated with the consumption of products contaminated with lead and cadmium.

Keywords: Bioaccumulation, Plomb, Cadmium

 










 

 
 
   
   
   
   
   
   
   
   
   
   
   
 
 
 
 
 
 
 
 
   
 
                         

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