Original Research Article

Evaluation of Oxidative Stress Parameters in Chronic Obstructive Pulmonary Disease before Medical Treatment

Ceylan Ayada^1*, Umran Toru Erbay²

¹Department of Physiology, Faculty of Medicine, İzmir Bakircay University, İzmir, Turkey
²Department of Thoracic Medicine, Faculty of Medicine, Kutahya Health Sciences University, Kütahya, Turkey

*Corresponding Author's E-mail: ceylan.ayada@bakircay.edu.tr

Phone: +90 (505) 633 12 63
+90 (232) 493 00 00-11475

Received: 27 February 2023  I  Accepted: 24 March 2023  I  Published: 29 March 2023  I  Article ID: MRJMMS23008
Copyright © 2023 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

Abstract

It is known that the pathophysiology of chronic obstructive pulmonary disease (COPD), a disease that develops against inhaled harmful chemicals and is characterized by progressive airway obstruction, is associated with oxidative stress. However, due to inconsistent findings, the oxidative status of COPD is not fully understood. It is thought that determining the oxidative state in detail may be an effective diagnostic criterion in the diagnosis of COPD. In addition, supplementing antioxidative mechanisms with diet or drugs is among the new treatment strategies. Total antioxidant status (TAS), total oxidant status (TOS), paraoxonase (PON1), arylesterase (ARES), total thiol (THIOL) levels were examined in COPD and control. Oxidative stress index (OSI) ratios were calculated. Oxidative balance did not change according to healthy individuals, although we observed a tendency to increase together in oxidative and antioxidative parameters in COPD patients. We observed that the tendency to increase antioxidative capacity in COPD patients is independent of PON1, ARES, and THIOL. When compared to the control group, the serum thiol parameter of the COPD group was shown to be significantly low. We think that the decrease in serum thiol parameter can be considered as a new indicator to confirm the diagnosis of COPD.

Keywords: Arylesterase (ARES), Chronic obstructive pulmonary disease (COPD), Paraoxonase (PON1), Total oxidative load, Total thiol (THIOL)