Original Research Article

Predictive Value of Delta Neutrophil Index, Interleukin 8 and C-Reactive Protein for Septic Patients

Pavlina Peneva^1*, Silviya P. Nikolova², Yana Bocheva³

¹St. Marina University Hospital – Varna, Medical University – Varna (Bulgaria)
²Department of Social Medicine and Healthcare Organization, Medical University – Varna (Bulgaria)
³Department of Clinical Laboratory and Immunology, St. Marina University Hospital – Varna, Medical University – Varna (Bulgaria)

*Corresponding Author's E-mail: p.peneva@abv.bg; Pavlina.Peneva@mu-varna.bg

Received: 18 June 2022  I  Accepted: 21 July 2022  I  Published: 27 July 2022  I  Article ID: MRJFST22056
Copyright © 2022 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

Abstract

In recent years, there have been an increasing number of studies on the Delta Neutrophil Index — DNI, C Reactive Protein – CRP and Interleukin 8 – IL8 as early markers for developing sepsis and risk of death. The study aimed to examine DNI, CRP and IL-8 in septic and non-septic patients and determine their predictive value as markers for sepsis. A prospective non-interventional single-centre clinical follow-up was performed. The study was conducted from January 2017 to July 2018 in a Bulgarian ICU in the city of Varna. DNI is a significantly critical marker for developing sepsis (Exp (B)=1.329, p= 0.007). DNI has an association with developing sepsis (r=0.363, p=0.001). ROC analysis showed a DNI value of 1.4(the bestcut-off value 1.4), with 73% sensitivity and 87% specificity (AUC 0.764, 95% CI 0.650-0.878, p=0.0001). CRP is a significant marker for severity of infection and shows the likelihood of sepsis events (Exp(B)=1.016, p=0.0001). The ROC curve results demonstrate that CRP, with 82% sensitivity and 76% specificity, predict sepsis development (AUC 0.885, 95% CI 0.813-0.956, p -0.0001). There is a correlation, indicating an IL-8 increase as a marker for sepsis (r = 0.461. P = 0.0001). IL8 was significantly higher in sepsis groups than in the control group (t=3,537, р<0.001). Our results show that DNI, CRP and IL-8 are reliable indicators of high predictability for the development of sepsis, and their careful monitoring will help in the early detection of these patients and their timely treatment.

Keywords: CRP, DNI, IL8, Infection, Sepsis, Septic shock