December 2021 Vol. 9 No.12

Abstract
Full text
Reprint (PDF) (127 KB)

Search Pubmed for articles by:
 

Original Research Article

Prevalence of Ovarian Cancer and Its Correlation with Age in Pakistan

Muhammad Waqar Mazhar^1*, Saira Saif¹, Asma Taj¹, Sohail Waris¹, Abdul Manan¹, Muhammad Irfan¹, Javaria Mahmood¹, Hira Tahir³, Fatima Mazhar²

^*1Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
¹Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
²Muhammad Nawaz Sharif University of Agriculture, Multan, Pakistan
³University of Health Sciences, Lahore, Pakistan.

*Corresponding Author Email: waqarmazhar63@gmail.com
Tel.: +923012222861 

Received: 18 November 2021  I  Accepted: 21 December 2021  I  Published: 24 December 2021  I  Article ID: MRJMMS21088
Copyright © 2021 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

Abstract

A group of diseases that originate from the different parts of ovaries and cause production of abnormal cells that divide uncontrolled themselves in the ovaries is known as ovarian cancer. OC is mainly classified into majorly three types on the base of three components of ovaries known as epithelium, stroma and germinal cells. Approximately, 7000 women develop OC and 4200 of them die every year in the UK. In Pakistan, the incidence of OC is increasing at the rate of around 13.6%. Approximately 70% cases are diagnosed at later stages. The blood sample was collected in the Layyah region. The CA125 identification through Elisa technique for their better identification on the basis of antibodies. Normal values of CA125 were considered less than 35 U/ml. The other tumor markers were also measured such as fibrinogen, prolactin, CA15.3, PT, APTT, INR, D Dimer, and CA19.9. The mean age of patients was 59.0 ± 8.1while the minimum and maximum age at which the tumor marker detection was 22 and 74 years. The number of patients was found in order of 25 >24 > 10 in 1st,2nd and 3rd age groups, respectively. The clinical histopathological test in the ovarian cancer patients show that the tumor size 5.21±3.42, fibrinogen 5.09±1.29, CA-199 (U/mL) 121.17±59.76, and D-dimer 0.61±0.31. The CA-125 level increase in ovarian cancer patients is indicated as a tumor marker.

Keywords: CA19.9, CA-125, Ovarian cancer, Prolactin level, Transvaginal ultrasound