December 2021 Vol. 9 No.12

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Original Research Article

Comparison of the mean total loss of mydriasis with topical ketorolac tromethamine 0.5% and nepafenac 0.1% during phacoemulsification

Fakhar Un Nisa¹, Muhammad Ayyub Khan², Rashida Riaz³, Samia Iqbal^4*, Madiha Tariq⁵

¹Consultant Ophthalmologist in Shiekh Zayed Hospital Lahore
²Assistant Professor Gomal Medical University, Dera Ismail Khan
³Consultant Ophthalmologist, Ophthalmology Department, Mayo Hospital Lahore
⁴Optometrist and Lecture, ophthalmology Department the University of Lahore
⁵Consultant Ophthalmologist in Al ahsan Trust Hospital, Lahore

*Corresponding Author's E-mail: samiaiqbal988@gmail.com

Received: 08 August 2021  I  Accepted: 23 September 2021  I  Published: 24 December 2021  I  Article ID: MRJMMS21073
Copyright © 2021 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

Abstract

Phacoemulsification with intraocular-lens implantation is the current surgical treatment of choice for cataract extraction. To prevent complications during surgery, there should be adequate pupillary dilation for better visualization of the posterior chamber. The objective of this study is to compare mean total loss of mydriasis with topical ketorolac tromethamine 0.5% and nepafenac 0.1% during phacoemulsification. The study design is randomized controlled trial and it was carried out in Department of Ophthalmology, Shaikh Zayed Hospital Lahore. The duration for this process is six months (August 2019 to January 2020). A total of 100 patients were selected from Ophthalmology Outdoor of Shaikh Zayed Hospital Lahore. The patients were randomly divided into two groups by lottery method, 50 patients in group A (Nepafenac 0.1%) and 50 patients in group B (Ketorolac tromethamine 0.5%). Five minutes later, tropicamide 0.5%, 1 drop every 15 minutes for 4 doses were instilled in both treatment groups. The two groups were compared with diameters of pupil was measured at different stages of cataract surgery and the mean values were compared across the two groups. The mean age of the patients in group A was 55.6±5.6 years and in group B was 54.6±5.7 years. The mean pupil diameter before surgery in group A was 7.9±0.4 and in group B was 8.0±0.5. The mean pupil diameter after surgery in group A was 6.4±0.6 and in group B was 5.7±0.5. The mean total loss of mydriasis in group A was 1.4±0.6 and in group B was 2.1±0.4. It is concluded from this study that Topical nepafenac has been shown to be a more effective inhibitor of miosis during phacoemulsification and provides a more stable mydriatic effect throughout the surgical procedure compared to topical ketorolac.

Keywords: Ketorolac Tromethamine 0.5%, Nepafenac 0.1%, Phacoemulsification, Total loss of mydriasis