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Airaodion
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Antifertility Effect of Ethanolic Leaf Extract of Carica papaya in Male Wistar Rats |
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Augustine I. Airaodion1*, Victor N. Okoroukwu2, Emmanuel O. Ogbuagu3, John A. Ekenjoku3, Uloaku Ogbuagu1 and Edith O. Airaodion4 |
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1Department
of Biochemistry, Federal University of Technology, Owerri, Imo
State, Nigeria Accepted October 14, 2019 |
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Abstract |
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The use of
Carica papaya leaves in folklore medicine for its
antimalarial and antidiabetic activities without reference to
its adverse effect is on the increase globally. This study
therefore sought to investigate the antifertility effect of C.
papaya leaves in male Wistar rats. Fresh and healthy leaves of
C. papaya disease were harvested from the Institute of
Agricultural Research and Training, Moor Plantation, Ibadan.
They were dried and extracted using soxhlet apparatus and
ethanol as the solvent. Toxicity test was carried out using
standard method. Thirty male Wistar rats were grouped into six
of five rats each. Animals in groups A, B and C were
administered normal saline for 10, 20 and 30 days respectively
via oral route. Those in groups D, E and F were similarly
treated but with 500 mg/kg body weight of leaf extract of C.
papaya. At the end of treatment, the animals were sacrificed
by cervical dislocation. The internal organs were exposed.
Testes and cauda epididymis were removed and kept in sterilized
glass. Male fertility parameters were determined using standard
methods. Ethanolic leaf extract of C. papaya causes decreased
sperm count, sperm motility and seminal pH while sperm mortality
and abnormality of spermatozoa increased significantly (p<0.05)
after 10, 20 and 30 days treatment respectively. These effects
were dependent on the number of days treated. The normal range
of sperm count, sperm motility, seminal pH and abnormality of
spermatozoa are essential factors for fertility. Any disturbance
of such normal range of seminal quality may affect the fertility
of animals. Thus, these changes in seminal quality of C.
papaya leaf treated-animals showed that C. papaya exhibits
antifertility activities but this does not automatically
translate to such effect on human. Therefore its effect on the
fertility of man can be further confirmed. |
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