September 2018 Vol. 6 No.9

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Original Research Article

Cardiometabolic risk factors in type 2 diabetic patients according to the definition for metabolic syndrome of International Diabetes Federation

Kamenova P.

Department of Diabetology, Clinical Center of Endocrinology and Gerontology, Medical University, Sofia, Bulgaria

*Corresponding Author’s E-mail: kamenovap@abv.bg
Tel: +359-888343952

Accepted September 10, 2018

Abstract

Identifying type 2 diabetic patients (T2D pts) with metabolic syndrome (MS) enables physicians for early and active treatment of cardiometabolic risk factors. The aim of the study was to assess characteristics of cardiometabolic risk factors in T2D pts according to the definition for MS of International Diabetes Federation (IDF) and to test the hypothesis whether IDF definition for MS could identify T2D pts with insulin resistance. Three hundred and eighty three (194 females, 189 males) T2D pts (mean±SD; age 62.2±10.4 yrs; body mass index 30.8±4.8 kg/m2) took part in the study. A manual hyperinsulinaemic euglycaemic clamp technique was used for a measurement of insulin sensitivity (IS), expressed as a glucose disposal rate (M), and homeostasis model assessment of insulin resistance (HOMA-IR). According to the definition of IDF, MS was diagnosed in 76.5% of the T2D pts (82% females, 70.9% males).The most common cardiometabolic risk factor in females was raised blood pressure (84.9%) and in males-reduced HDL cholesterol (76.9%). IS of the MS pts M 3.238±1.673 was significantly lower compared to that of non MS pts M 6.893±3.846 (mg/kg/min), p=0.007. HOMA-IR of the MS pts 6.02±1.69 was significantly higher compared to that of non MS pts 3.07±1.27, p<0.001. In conclusion, T2D pts, included in our study, were presented with multiple cardiometabolic risk factors. According to our data, IDF definition for MS could identify T2D pts with insulin resistance. Multiple risk factor treatment strategy is required for reduction of global cardiometabolic risk.

Keywords: Cardiometabolic Risk Factors, Insulin Resistance, Insulin Sensitivity, International Diabetes Federation, Metabolic Syndrome, Type 2 Diabetes Mellitus