July 2018 Vol. 6 No.7

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Original Research Article

Do matrix metalloproteinases have effects on transcarpal ligamentum hypertrophy in carpal tunnel syndrome?

Abdullah Talha SIMSEK¹ and Numan KARAARSLAN^2*

¹M.D. Namik Kemal University School of Medicine, Department of Neurosurgery, 59100, Tekirdag, Turkey.
²Assist. Prof. M.D.; Namik Kemal University School of Medicine, Department of Neurosurgery, 59100, Tekirdag, Turkey.

*Corresponding Author’s E-mail: numikara@yahoo.com
Pbx: +9028 2250 5500

Accepted July 09, 2018

Abstract

It is known that matrix metalloproteinases (MMPs) play a role in the physiopathological cycle of different tissues. In this study, it was aimed to investigate whether the MMPs in the stromelysin and collagenase groups were the main determinant in the carpal tunnel syndrome. In this prospective study, the cases with carpal tunnel syndrome (CTS), which met also inclusion criteria, were evaluated immunohistopathologically. The alpha significance value was accepted as <0.05, and the results were evaluated at a 95% confidence interval. There was no statistically meaningful correlation observed between the operating hand electromyo-graphy (EMG) results and the MMPs expressions when examining MMPs staining patterns (p>0.05). However, it was remarkable that the expression of these three enzymes was positively correlated with CTS. We believe that the data obtained from this study, in which the MPPs enzyme family has been evaluated in carpal tunnel syndrome, will have an important place in future studies in which these and similar pathologic treatments will be investigated.

Keywords: Carpal tunnel syndrome, matrix metalloproteinases, transverse carpal ligament.