July 2018 Vol. 6 No.7

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Original Research Article

The Incidence of Neutropenia Post Kidney Transplant Patient at Prince Sultan Military Medical City

Reem ALSharqi¹, Linah ALMuhawwis², Haddah AlKhaldi², Abdulaziz Alanizi¹, Faris AlAbdulkareem¹, Mohammed M. Alanazi³ and Faris Q. Alenzi^4,5*

¹King Abdulaziz Medical City, Riyadh, KSA
²Prince Sultan Military Medical City, Riyadh, KSA
³Fronsic Medicine services, Riyadh, KSA
⁴Dar Shefa Hospital, Riyadh, KSA
⁵Professor of Immunology, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University (PSAU), Al-Kharj, Saudi Arabia

*Corresponding Authors’ E-mail: fqalenzi@ksu.edu.sa

Accepted July 15, 2018

Abstract

There are indirect evidences showed that there is an association between neutropenia and some of the medications such as Anti-thymocyte Globulin (ATG), Mycophenolic acid (MPA) and Tacrolimus (TAC) that are use for kidney transplant patients. It is evidenced that are driven upon reducing dose or holding these medications. The prolonged and severe neutropenia can lead to serious infections and allograft rejection. A retrospective cohort study where patients had been tackled over six months post kidney transplantation. The 81 patients who had transplantation between January 2014 and December 2014 were identified and followed up using hospital system and patients medical records. The incidence of neutropenia was 11.11%. The findings show an association between neutropenia post kidney transplant and some factors including: female gender and the use of immunosuppressant medications, like MPA (P>0.05). Eighty one patients were tackled retrospectively for 6 months. The incidence of neutropenia were 11.11%. TAC and MPA were used in all of patients. This study claimed that these medications might increase the risk of neutropenia post kidney transplant; P<0.05. The findings of the present study indicate the holding MPA and using G-CSF is significantly effective to accelerate the recovery of neutropenia. The incidence of neutropenia in this study was relatively high post kidney transplant with female gender and MPA alone or in combination with TAC being potentially associated factors with neutropenia.

Keywords: Neutropenia, Kidney transplant, Medication, Immunosuppressant