October 2017 Vol. 5 No.10

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Original Research Article

Will it be possible to prevent lumbar degenerative disc diseases in the future by means of vitamin D receptor gene manipulation?

Numan Karaarslan^1*, Yasin Emre KAYA², Ibrahim YILMAZ³, Hanefi OZBEK⁴, Betul EKIZ BILIR⁵, Necati KAPLAN⁶, Duygu YASAR SIRIN⁷, Yener AKYUVA⁸, Mehmet Sabri GURBUZ⁹, Kadir OZNAM¹⁰, Semih AKKAYA¹¹, Cagri Ata MUTLU¹², Olcay GULER¹³, Ozkan ATES¹⁴ and Mahir MAHIROGULLARI¹⁵

¹Assist. Prof. M.D., Namik Kemal University School of Medicine, Department of Neurosurgery, 59100, Tekirdag, Turkey.
²Assist. Prof. M.D., Abant Izzet Baysal University School of Medicine, Department of Orthoaedic and Traumatology, 14000, Bolu, Turkey
³Medical Pharmacologist; pharmacist, Istanbul Medipol University School of Medicine, Department of Medical Pharmacology, 34810, Istanbul, Turkey
⁴Prof. M.D., Ph.D; Istanbul Medipol University School of Medicine, Department of Medical Pharmacology, 34810, Istanbul, Turkey
⁵M.D., Republic of Turkey, Ministry of Health, State Hospital, Department of Endocrinology, 59100, Tekirdag, Turkey
⁶Assist. Prof. M.D., Istanbul Rumeli University, Reyap Corlu Hospital, Department of Neurosurgery, 59680, Tekirdag, Turkey
⁷Assist. Prof. Ph.D.; Namik Kemal University, Faculty of Sciences and Arts, Department of Molecular Biology and Genetics, 59100, Tekirdag, Turkey
⁸M.D., Gaziosmanpasa Taksim Training and Research Hospital, Department of Neurosurgery, 34433, Istanbul, Turkey
⁹Assist. Prof. M.D., Istanbul Medeniyet University School of Medicine, Department of Neurosurgery, 34000, Istanbul, Turkey
¹⁰Assist. Prof. M.D., Department of Orthopaedic and Traumatology, Istanbul Medipol University School of Medicine, 34214, Istanbul, Turkey
¹¹Assoc. Prof. M.D., Private Surgery Hospital, Department of Orthopaedic and Traumatology, 20070, Denizli, Turkey
¹²M.S., Acibadem University School of Medicine, Department of Medical Science, 34752, Istanbul, Turkey
¹³Assoc. Prof. M.D., Bahcelievler Medicalpark Hospital, Department of Orthopaedic and Traumatology, 34180, Istanbul, Turkey
¹⁴Prof. M.D., Esenyurt University, Department of Neurosurgery, Esencan Hospital, 34517, Istanbul, Turkey
¹⁵Prof. M.D., Memorial Health Group, Department of Orthopaedic and Traumatology, 34758, Istanbul, Turkey

*Corresponding Author’s E-mail: numikara@yahoo.com
Pbx: +9028 2250 5000
Fax: +9028 2509 9900

Accepted October 09, 2017

Abstract

It is primarily aimed to study polymorphisms in vitamin D receptor gene (VDR), which is one of the genetic factors having a role in the formation of lumbar pathologies and/or causing higher incidence of pathologic processes. Secondarily, it is aimed to create pre-data which may help professionals to administer more effective and protective interventions in this area. Without any language preference, we searched US National Library of Medicine National Institutes of Health, Embase, OVID, Cochrane Library database of clinical trials from 1989 to Mar 11 to 2017 Mar 12, and traced all the references of incorporated documents. The data were evaluated by using descriptive statistics. Results were shown as amount or frequency (%). In literature, some vitamin D receptor gene (VDR) polymorphisms have been found in relation to widespread osteochondral diseases. When VDR polymorphisms, vitamin D level and intervertebral disc pathologies have been examined, a satisfactory answer to the question whether specific pathologies could be suppressed in terms of genetics has not been found. By means of this study, it would be understood the genetic factors inhibiting physio pathological process concerning lumbar degenerative disc disease or the genetic factors playing role in identifying physio pathological process related to lumbar degenerative disc disease by defining them. Accordingly, effective and contraceptive treatment of lumbar degenerative disc disease might be ensured soon.

Key Words: Intervertebral disc degeneration, lumbar canal stenosis, lumbar disc herniation, lumbar spinal stenosis, lumbar spondylosis, lumbar spondylolisthesis, Vitamin D receptor gene polymorphism.