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Kuo
T
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Depletion of nutrients stimulates further propagation of cancer cells |
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Tsun-Cheng Kuo1* and Feng-Ming Ho2 |
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1Department
of Cosmetic Science, Chia-Nan University of Pharmacy and
Science, 60, Erh-Jen RD., Sec. 1, Jen-Te, Tainan (Zip code 717),
Taiwan Accepted January 23, 2017 |
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Abstract |
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In present study,
B16-F10 cell line was grown in 96-well culture plate with
different amount of culture medium. We expected the cell
proliferation rate decreased accompanied with lower volume of
medium. Interestingly, in 100 l culture medium, cell number of
B16-F10 cells was significantly increased. This result indicated
that low nutrient condition would not inhibit cell
proliferation, but stimulated cell growth. To further confirm
this notion, STO cell was cultured under different amount of
culture medium. The result was in line with B16-F10 cells,
growth rate of STO cells was significantly increased in 80 l.
Above result suggested such depletion of nutrients stimulates
further propagation of cancer cells. Cancer could be considered
as a response outcome when cells strive to survive against
stress. In present study, cells were grown with higher
proliferation rate in lower supplement of culture medium. This
data suggested that stress could stimulate the propagation of
cells by lowering the nutrients of cell culture medium. This
observation proposes a cancer formation mechanism, which
provides a new research direction of cancer treatment. The
stress factors that might cause tumorogenesis are diverse, and
perhaps are not easy to remove. Finding a method or medicine
that could inhibit cell proliferation under stress provides an
opportunity to develop the key indicators and a method to
effectively prevent cancer formation. |
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