October 2016 Vol. 4 No.10

Search Pubmed for articles by:
 

Short Communication

FnBPs: An effective adhesion molecule in Mycobacterium tuberculosis pathogenesis

Siuli Shaw and Laxman S. Meena*

CSIR-Institute of Genomics and Integrative Biology, Council of Scientific and Industrial Research, Mall Road, Delhi-110007

*Corresponding Author’s E-mail: meena@igib.res.in, Laxmansm72@yahoo.com
Tel.: 011-27666156
Fax: 011-27667471

Accepted October 25, 2016

Abstract

A significant step during infection is the attachment of pathogen with the host cell surface. Mycobacterium tuberculosis is a major human pathogenic strain that invades host cell by using several successful mechanisms. FnBPs are important protein present on microorganism which specifically binds with the Fn protein of host. Antigen85 complex and PE_PGRS family shows fibronectin binding properties that has evidenced important role in many bacterial adherence including species of mycobacterium. FnBPs plays a vital role in adhesion with the host surface as well as in various signalling pathway.

Keyword: Ag85, Fibronectin, Fibronectin binding protein, M. tuberculosis, PE_PGRS