October 2016 Vol. 4 No.10

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Original Research Article

Obestatin and Copeptin Levels in Egyptian Polycystic Ovary Patients and their Relation to Obesity, Insulin Resistance and Cardiovascular Risk

Abeer I. Abd El-Fattah¹, Adel A. Elboghdady², Mahmoud M. Kamel^3* and Elfeshawy S. Mohamed⁴

¹Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University
²Department of Obstetrics and Gynecology, Faculty of Medicine (Boys), Al-Azhar University
³Department of Clinical pathology, National Cancer Institute, Cairo University
⁴Department of Radiology, Faculty of Medicine (Boys), Al-Azhar University

*Correspondence Author’s E-mail: mm.kamel@yahoo.com
Telephone: +201018470990

Accepted October 12, 2016

Abstract

The aim of this study is to investigate the correlations between the serum levels of obestatin and copeptin, carotid artery intima-media thickness (CIMT), and brachial artery flow mediated dilatation (FMD) in obese and non-obese women with PCOS. Secondly to investigate their relationship with each other and with clinical, metabolic, hormonal parameters and cardiovascular risk factors. We analyzed 54 patients with PCOS and 20 age-matched healthy women as controls. PCOS patients were divided into two groups based on body mass index (BMI): obese group (BMI > 30 kg/m², n = 28) and non-obese group (BMI < 30 kg/m², n = 26). Serum copeptin and obestatin levels, insulin homeostasis model assessment for insulin resistance (HOMA-IR), CIMT and brachial artery FMD were determined and compared among the groups. Women with PCOS, especially obese ones, had higher triglycerides, HOMA-IR, hirsutism score, total testosterone, CRP, systolic and diastolic blood pressure, and waist-to-hip ratio (WHR), and lower HDL. Serum obestatin levels were significantly lower in obese PCOS group than non-obese and control. While Serum copeptin levels were significantly higher in obese PCOS group than non-obese and control. Brachial artery FMD was lower in the PCOS groups than control. Obestatin was positively correlated with cardiovascular risk factor (FMD), whereas copeptin was negatively correlated with FMD. Obestatin and copeptin may provide useful information regarding future cardiovascular risk in PCOS patients as obestatin was negatively correlated and copeptin was positively correlated with cardiovascular risk factor (FMD).

Keywords: Cardiovascular Risk, Copeptin, Insulin resistance, Obesity, Obestatin, Polycystic ovary