May 2016 Vol. 4 No.5

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Original Research Article

PlGF and Pre-eclampsia Risk in a Group of Iranian Pregnant Women

¹Farah Farzaneh, ^*2Arezu Karimpur-zahmatkesh, ¹Maryam Sohanaki, ³Karimeh Samadi, ⁴Mehdi Yaseri and ⁵Mohammad Reza Sohrabi

¹Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
²Medical Genetics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
³Obstetrics and Gynecology Department, Imam Hossein HP, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴Department of Biostatics, Tehran University of Medical Sciences, Tehran, Iran
⁵Social Determinants of Health Research Center and Department of Community Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

*Corresponding Author’s E-mail: A.karimpur.z@gmail.com, Arezu_kzh@yahoo.com

Accepted March 14, 2016

Abstract

Pre-eclampsia is an abnormal situation, characterized by hypertension and proteinuria in pregnancy due to widespread endothelial dysfunction. This disorder is a major cause of maternal morbidity and mortality in worldwide. Pay attention to significant incidence of pre-eclamptic toxaemia (PET) in pregnancy -as a physiologic phenomenon-, research about pathophysiology and invent of tests for early detection is important in Primary Health Care. Amongst, studies have been shown role of some angiogenic factors such as VEGF, PlGF (Placental Growth Factor) … in pathogenesis of PET. Many of these studies have indicated alleviation of VEGF and PlGF level in maternal blood circulation. These factors play a role in placental vessels development. In fact, serum that is got patients with disorder induces many physiological changes in endothelial cells indicating the presence of a circulating imbalance. Judging from these reasons, we examined relation between PlGF and PET risk in pregnant women. We studied 96 pregnant women (with one risk factor such as first pregnancy…) which were referred to Imam Hussein Hospital, SBMU, Tehran. In this study, PET has been associated with low levels (< 100 pg/mlit) of PlGF (P-value=0.007). Our study supports possible role of PlGF in pre-eclampsia occurrence. Results of this and other similar studies may use establishing early diagnosis test for PET. This can help to decrease maternal and neonatal morbidities and mortality.

Keywords: PlGF (Placental Growth factor), Pre-eclampsia, Pregnancy