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Nabil
AH
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Antihyperlipidemic effect of pomegranate peel and Iranian fenugreek extracts on cholesterol-rich diet-induced hypercholesterolemia in guinea pigs |
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Nabil A. Hasona1,2*, Mohammed Q. Ahmed1, Turki A. Alghassab1, Muath A. Alghassab1 and Abdullah A. Alghabban1 |
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1College
of Medicine, Ha’il University, Ha’il, KSA Accepted April 11, 2016 |
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Abstract |
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Composition of
the diet played an important role in the management of lipid and
lipoprotein concentrations in blood. Therefore, the aim of this
study was to evaluate the effects of pomegranate peels and
Iranian fenugreek extracts on the liver, cardiac and antioxidant
status of the serum and tissues from diet-induced
hypercholesterolemic guinea pigs. The guinea pigs were divided
into six groups (10 per group). The first group served as normal
control. The second and third groups were treated with Iranian
fenugreek and pomegranate extract alone, respectively. The
fourth group was fed with hypercholesterolemic diet only for 30
days; whereas the fifth and sixth groups were treated with
Iranian fenugreek extract or with pomegranate extract
respectively and fed with hypercholesterolemic diet also for 30
days. Blood and tissue were removed for further biochemical
analysis. Oral treatment with extracts of pomegranate peel and
Iranian fenugreek demonstrated significant protective effects on
all the biochemical parameters studied including lipid profile,
antioxidant status and liver functions tests. These results
suggest that pomegranate and Iranian fenugreek extended
protection against various biochemical changes in
hypercholesterolemic guinea pigs. Thus, methanolic extract of
pomegranate and Iranian fenugreek are recommended to prevent the
development of hypercholesterolemic and its complications. |
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