February 2015 Vol. 3 No. 2

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Original Research Article

The chemopreventive effects of onion and garlic oils against valproic acid-induced toxicity

Eman S. Abdel-Reheim^1,2*, Osama M. Ahmed¹, Mohamed B. Ashour¹ and Walaa H. Ahmed¹

¹Physiology Unit, Zoology Department, Faculty of Science, Beni-Suef University, Egypt
²Zoology Unit, Biology Department, Faculty of Sciences, Al-Taif University, Saudi Arabia

*Corresponding Author's E-mail: em4salah@yahoo.com/e.salah@tu.edu.sau

Accepted January 12, 2015

Abstract

Valproic acid (VPA) is a first-line antiepileptic drug that is used clinically in the treatment of various seizure disorders, in the management of bipolar disorder and migraine. In this study we wish to use natural oils, depending on their antioxidant effect, to reduce the side effects of the widely used VPA. We studied this effect on the highly affected organs (liver, kidney and heart). The animals were divided into five groups: the 1st was the control one, the 2nd was VPA treated group, the 3rd, the 4th and the 5th were the groups treated with onion, garlic or their mixture respectively. The study showed a significant increase in liver and kidney functions, myocardial toxicity and oxidation shift in VPA treated rats and all were ameliorated after treatments especially with the oils mixture.

Keywords: Valproic acid- toxicity- onion oil- garlic oil.