August 2015 Vol. 3 No. 8

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Original Research Article

Status of estradiol in premenopausal women with essential hypertension in Karkuk City: A cross-sectional study

Asst. Prof. Dr. Faisal GH. Al-Rubaye (PhD; MBChB.)^1*, Asst. Prof. Dr. Yaldiz Hasan Tahsein (PhD; BSc.)² and
Lecturer Dr. Esraa Abdulkareem Mohammed (F.I.C.O.G; C.A.B.O.G; MBChB.)³
 

¹Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University
²Department of Biochemistry, College of Medicine, Karkuk University
³Department of Obstetrics and Gynaecology, College of Medicine, Karkuk University

*Corresponding Author’s E-mail: faisal3ghazi@yahoo.com
Tel: +9647702640792

Accepted May 25, 2015

Abstract

High Blood Pressure (BP) results from a complex interaction of genetic, environmental and demographic factors. The level of endog¬enous estrogens may be a critical risk factor in hypertensive diseases, Estrogens exert an effect on the endothelium and smooth muscle cells in the vascular wall, where they inhibit cell proliferation and induce vasodilatation. The aim of this study is to assess the status of estradiol in women with HyperTensioN (HTN). The present study is a cross-sectional study that was carried out between 2011 to 2012) at Karkuk Teaching Hospital/Karkuk governorate/Iraq. Parameters measured include serum estradiol and calculating Body Mass Index BMI) in premenopausal women with HTN. The results of this study shows a total of 100 Premenopausal women with HT were involved in this studyG1: (n=100). A matching group of hundred apparently healthy women who were included as controls (n=100), Serum estradiol was significantly reduced in Premenopausal women with HT G1 when compared with controls (p < 0.05); a significant negative correlation was found between estradiol and Body Mass Index (n=100; r = 0.8; P< 0.05). In conclusion, women with HT were having low level of serum estradiol compared with controls; this estradiol was negatively correlated with body mass index. The above results suggest importance of hormone therapy in maintenance of vascular tone.

Keywords: Estradiol, hypertension, premenopose