May 2014 Vol. 2 No. 5

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Original Research Paper

HER-2/neu Expression is not correlated to stage of ovarian cancer

Ryan Saktika Mulyana*, I. Ketut Suwiyoga and I. Gede Mega Putra

Department of Obstetrics and Gynecology, Faculty of Medicine, Udayana University, Bali Sanglah

*Corresponding Author's E-mail: ryan_mul@yahoo.com; Tel: +6281805619588

Accepted May 05, 2014

Abstract

Cross-sectional study, study was held in Obstetrics and Gynecology department, Anatomic Pathology and Medical Records of Sanglah General Hospital Denpasar, which was conducted from July 2011 until July 2013 with 44 pieces sample of paraffin blocks. Paraffin blocks sample are grouped based on the stage of ovarian cancer, namely: ovarian cancer stage I, II, III, and IV. Then each group of stage was examined the expression of HER2/neu by immunohistochemical techniques and assessing their correlation between HER2/neu expression and stage of ovarian cancer using the Spearman test. Mean age, Body Mass Index (BMI), parity, and history of hormonal contraceptives on four groups of ovarian cancer stage were homogeneous. Based on the correlation test was obtained that correlation r value was 0.203 (p = 0,185), indicated that there was no correlation between the stage of ovarian cancer and expression of HER2/neu. Her2/neu expression was not correlated with stage of ovarian cancer.

Keyword: Her2/neu expression and stage of ovarian cancer.