October 2020 Vol. 8 No.10

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Original Research Article

New Perspective in Obstructive Sleep Apnea Syndrome – The Use of Biomarkers as a Screening Tool

Diana-Cristina Protasiewicz-Timofticiuc^1,2*, Mihaela Vladu^1,3, Adela Stefan Firanescu⁴, Maria Moța¹

¹University of Medicine and Pharmacy, Craiova, Romania
²Department of Diabetes, Nutrition and Metabolic Diseases, Clinical County Emergency Hospital, Craiova, Romania
³Department of Endocrinology, Filantropia Clinical County Hospital, Craiova, Romania
⁴Department of Diabetes, Nutrition and Metabolic Diseases, County Hospital, Calafat, Romania

*Corresponding Author's E-mail: diana_protasiewicz@yahoo.com
Tel: +40 749103782

Received: 06 October 2020  I  Accepted: 21 October 2020  I  Published: 23 October 2020  I  Article ID: MRJMMS-20-162
Copyright © 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

Abstract

The sedentary lifestyle and extreme environmental changes led to a 3-fold increase in obesity prevalence since 1975. Although obesity can be prevented, once appeared it represents a major risk factor in developing/progression of obstructive sleep apnea syndrome (OSAS) and other comorbidities. Nowadays, the prevalence of OSAS is also continuously growing in an exponential mode, making it obvious that a new approach is needed. The association between obesity and OSAS has been described since ancient time and only recently has become of great interest worldwide because of its great impact on people’s quality of life. Obesity and OSAS represent a major health problem because of the increased risk of cardiovascular diseases (CVD), systemic inflammation, metabolic disorders, dyslipidemia, non-alcoholic fatty liver disease (NAFLD), hyperuricemia, gout, chronic kidney disease (CKD), depression, anxiety, cognitive impairment, neurological disorders, excessive daytime sleepiness, decreased vigilance leading to road traffic accidents. The polysomnography is considered to be the “gold standard method” to diagnose OSAS and its severity, but finding a new and non-invasive screening tool is becoming vital because of the worldwide disease impact upon the quality of life and also by judging the need of achieving a long-lasting therapeutic control.

Keywords: Biomarkers, Cardiovascular diseases, Non-alcoholic fatty liver disease, Obesity, Obstructive sleep apnea, Type 2 diabetes mellitus