October 2020 Vol. 8 No.10

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Case Report

Multiple primary tumors in a young adult female (Li-Fraumeni syndrome)

Walid Shalata^1*, Roni Gillis², Abu Saleh Omar³, Roxana D. Grinberg¹, Raul Bitran¹, Ala Eddin Neime⁵, Wenad Najjar⁴, Ali Abu-Juma'a⁵, Alexander Yakobson¹, Yulia Dudnik¹

¹The Legacy Heritage Oncology Center and Dr. Larry Norton Institute, Soroka Medical Center and Ben-Gurion University, Beer-Sheva, Israel
²Goldman Medical School, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.
³Department of Dermatology and Venereology, The Emek Medical Centre, Afula, Israel.
⁴Department of Neurosurgery, Hadassah Medical Centre, Jerusalem, Israel.
⁵Department of Internal Medicine, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.

*Corresponding Author's Email: walid.shalata@gmail.com
Cell: +972 (0)54 2967100

Received: 28 August 2020  I  Accepted: 16 September 2020  I  Published: 25 October 2020  I  Article ID: MRJMMS-20-136
Copyright © 2020 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0.

Abstract

The objectives of this study was to describe the occurrence of multiple primary tumors in a young adult as an example of the Li-Fraumeni syndrome and emphasize the difficulty and complexity of treatment. Young adult patients with multiple tumors are rarely reported. In our case, a 23-year-old female presented over a period of 14 months with primary tumors in the right adrenal, lung, breast and brain. She had a family history of lung cancer, breast cancer and astrocytoma grade II of the brain. The patient underwent resection of tumors of the right adrenal and left lower lung segment as well candidates for preventive bilateral mastectomy. Family history of cancer and the occurrence of multiple tumors at a young age should lead to suspicion of Li-Fraumeni Syndrome.

Keywords: Brain tumor, Breast tumor, Li-Fraumeni syndrome, Lung adenocarcinoma, Pheochromocytoma