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Abasi
L
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Immunological profile (GAD, ICA, insulin receptor antibodies) in type Ι DM patients, our experience at KHMC |
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Dr. Lamees Abasi*, Dr. Bahieh Al-abadi, Dr. Mansour Al-hiary, Dr. Maha Al-amer and Dr. Khaldoun Alsraiheen |
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MD. Specialist
Clinical Pathology/immunology, King Hussein Medical Center,
Amman-Jordan Accepted March 05, 2019 |
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Abstract |
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The aim of this
study was to determine the frequency of autoantibodies among
Jordanian patients with diabetes mellitus type 1. A total of 128
subjects were included with age range between 1year and 14
years, 45.3% (58) of which were female and 54.7% (70) were male.
Samples were analysed for anti-Glutamic acid decarboxylase,
anti-insulin, and anti-islet cell antibodies using mosaic
pancreas (monkey)/cerebellum (monkey) instructions for the
indirect immunofluorescence assay, Euroimmun, Germany. One
hundred and twenty eight subjects with T1DM were enrolled in
study; 58 female (45.3 %) and 70 male (54.7%). The overall
frequency of any autoantibodies was 36.7% (47 of 128
subjects).Anti-GAD, anti- Islet cell and anti-insulin antibodies
were detected in 30.46% (39 subjects), 25.78% (33 subjects), and
23.43% (30 subjects) respectively table-1. Anti-GAD and
anti-islet cell antibodies were more frequent in male, and
anti-insulin antibodies were more frequent in female's figure 1,
2, 3. Frequency of multiple antibodies more than one was
observed in 38 patients (29.68%); whereas only one antibody
(anti-insulin antibodies) was observed in 28 patients (21.87%).
18 of 19 subjects with positive anti-GAD antibodies had positive
anti-islet cell antibodies. About one third of diabetes mellitus
patients from Jordan had presence of autoantibodies such as
anti-GAD, anti-islet cell, and anti-insulin in a single form or
in a combination, which is suggest of having diabetes mellitus
type 1. We recommend further large studies to be done in
different areas of country. |
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