September 2018 Vol. 6 No.9

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Original Research Article

Toxic effects of lead-induced Damage in liver of rats male and the role of ethanolic ginseng extract as protective agents (histological and physiological)

Sawsan A. Ali¹, Karim H. Al-Derawi^2* and Nasir Abd Ali Al-Mansour²

¹Department of histology and Anatomy, College of Veterinary Medicine, University of Basrah, Iraq.
²Department of Biology, College of Science, University of Basrah, Iraq

*Corresponding Author’s E-mail: Karimhalderwi59@gmail.com

Accepted September 13, 2018

Abstract

This study was to determine the hepato protective and activity effects of ethanolic extract of Panax ginseng roots on the biochemical and histology of liver of adult Rattus norvegicus rats following lead – induced hepatotoxicity. Twenty-Four male rats divided into four groups: Group T1 control; Group T2 PbAc (administrated orally with PbAc, 100 mg/kg); group T3 P. ginseng (100 mg/kg+PbAc); group T4 P. ginseng (200 mg/kg) daily administrated for 2 months. PbAc treatment alone induced hepatotoxicity, evidenced by significant increases in BBL and lipid peroxidation, malondial dehyde (MDA) Level. Histological results reveal alteration of liver structure including congestion and dilated of central vein, hepatic vacuolation, infiltration of inflammatory cells with necrosis of hepatocyte and hyperplasia. Treatment with P. ginseng in PbAc in toxicated male rats showed some ameliorative effect to PbAc toxicity in low dose, while showed clear ameliorative effects to PbAc toxicity in high dose. In conclusion, this study shows that Panax ginseng root extract has ratable ability to prevent liver damage caused by lead toxicity.

Keywords: Liver histology, Lead acetate, Toxicity, Antioxidants, Ginseng