November 2018 Vol. 6 No.11

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Original Research Article

Herbal Kushta of Cuprous oxide as a Nephrotoxic Agent - An Experimental Study

Hira Kareem¹, Maryam Rashid^2*, Nadia Naseem³ and A. H. Nagi⁴

^1,3,4University of Health Sciences Lahore, Pakistan
²Akhtar Saeed Medical and Dental College Lahore, Pakistan

*Corresponding Author’s Email: maryam.rashid107@gmail.com

Accepted November 05, 2018

Abstract

The aim of this research is to evaluate the effects of cuprous oxide preparations of Kushta on renal function tests. This study was conducted at Pathology Department of University of Health Sciences Lahore and it was an experimental study. Thirty albino rats were selected and divided into three groups. The control group A was fed on standard pellet rodent diet and tap water. The experimental group B was fed single dose of cuprous oxide preparation of Kushta (0.15mg/kg of body weight) for 24 weeks while experimental group C was fed double dose of cuprous oxide preparation of Kushta (0.5mg/kg of body weight) for 24 weeks. Renal function tests were calculated once at the start of experiment and then after every 6 weeks up to 24 weeks. Results showed that renal function tests in terms of serum creatinine level and proteinuria were deranged evident on biochemical analysis. When the Control group A on normal diet was compared with the experimental group B and C, statistically significant difference (p<0.05) was noticed in terms of renal function tests. It is therefore concluded that cuprous oxide preparations of Kushta deranged renal function tests in terms of serum creatinine levels and proteinuria.

Keywords: Kushta, heavy metals, cuprous oxide, renal toxicity