June 2018 Vol. 6 No.6

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Review

Systemic Lupus Erythematosus and Pregnancy Outcomes

Samar H. Goma^*, Essam A. M. Abda, Zahraa I. Selim, Eman H. El-Hakeim and Shimaa Mohamed

Department of Physical Medicine, Rheumatology, and Rehabilitation, Assiut University Hospitals, Assiut, Egypt.

*Corresponding Author’s E-mail: samarhassanein2010@yahoo.com
Tel.: +2 01061828586

Accepted June 22, 2018

Abstract

Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune disease. It is characterized by the development of autoantibodies and immune complexes in association with a wide variety of clinical manifestations and tissue damage. Several defects of multiple immunological components play a role in the pathogenesis of SLE. Despite the advent in the management of SLE pregnant patients, SLE poses a higher risk of prenatal morbidity and mortality when compared to normal pregnant females. Pregnancies for patients with SLE pose a greater risk of fetal loss, intrauterine growth retardation, prematurity, preeclampsia, and low birth weight. Pregnancy can both trigger and cause SLE flares. In this review we will discuss the effect of SLE on pregnancy, fertility, when and how to time pregnancy, organ involvement during pregnancy (eg. Lupus nephritis), clinical and serological factors associated with adverse maternal and fetal outcomes in SLE. At last the management of pregnant female patient with SLE.

Keywords: pregnancy, SLE, maternal outcomes, fetal outcomes