March 2016 Vol. 4 No.3

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Original Research Article

Diagnostic Value of Fecal Calprotectin Point of Care Testing in the Pediatric Practice

Rayna Shentova^*1, Tsvetelina Velikova², Christo Zhelev¹, Emilia Panteleeva¹, Penka Yaneva¹ and Petio Hadjiiski¹

¹Department of Gastroenterology and Hepatology, University Pediatric Hospital “Prof. Ivan Mitev”, Sofia, Medical University of Sofia, 16, Acad. Iv. Evst. Geshov Blvd., 1606 Sofia, Bulgaria
²Laboratory of Clinical Laboratory and Clinical Immunology, UMHAT “St. Iv. Rilski”, Sofia, Medical University of Sofia 15, Acad. Iv. Evst.Geshov Blvd.,1431 Sofia, Bulgaria

*Corresponding Author’s E-mail: rshentova@yahoo.com
Tel: +359 2 81 54 312
Fax: +359 2 81 54 312

Accepted March 20, 2016

Abstract

We evaluated 54 children – 24 children with inflammatory bowel disease, 15 with other non-infectious intestinal diseases and 15 healthy controls. All of the children provided fresh fecal samples for measurement of Fecal Calprotectin (FC). FC concentration was assayed by two methods – quantitative point of care test and ELISA test. The mean FC levels were significantly increased in all of the patients with intestinal inflammation. There was a strong correlation between the results obtained from the point of care test and the ELISA assay. FC point of care testing is a useful non-invasive screening tool in the pediatric practice.

Key words: Fecal calprotectin, Intestinal inflammation, Point of care testing