November 2014 Vol. 2 No. 11

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Original Research Article

Diagnostic possibilities of ECP and eosinophilia in nasal mucosa in children with different types of rhinitis

Spasova A. and *Velizarova S.

University Clinic for Pulmonary Diseases in children, MU-Sofia, Bulgaria

*Corresponding Author's E-mail: velizarovasv@gmail.com

Accepted November 07, 2014

Abstract

Early diagnosis of rhinitis in children is important both for the therapy, as well as for prophylaxis of these diseases. The aim of this study is to evaluate the differential diagnostic possibilities of ECP in children with rhinosinusitis. In our study, 50 patients with clinical symptoms of rhinitis are divided in the following three groups: in Group 1 are included children with allergic rhinitis (n = 15, 30%), Group 2 – children with non-allergic rhinitis (n = 12, 24%) and Group 3 – non-allergic rhinitis with eosinophilia syndrome (n = 23, 46%). In each patient, ECP in serum and eosinophilia in nasal secretion were examined. The serum ECP levels were measured using immune methods (Pharmacia CAP). There is no statistically significant difference in the ECP levels between the three groups, although the mean ECP concentration is higher in asthmatics with allergic rhinitis. We found that the degree of allergic inflammation in allergic rhinitis with asthma can affect the serum ECP levels.

Keywords: Allergic rhinitis in children, bronchial hyperreactivity, bronchospasm, rhinosinusitis