June 2014 Vol. 2 No. 6

Search Pubmed for articles by:
 

Review

Rabies Virus Proteins and their Mechanism of Pathogenecity

Nega Getachew*, Biruk Tesfaye and Mebratu Asaye
 

College of Veterinary Medicine and Agriculture, Addis Ababa University, P. O. Box 34, Debre Zeit, Ethiopia

*Corresponding Author's E-mail: amhaget6@gmail.com

Accepted June 23, 2014
 

Abstract

Rabies is a zoonotic viral disease. Rabies is transmitted by bites of a rabid animal. The rabies virus encoded five proteins, namely glycoprotein, nucleoprotein, phosphoprotein, matrixprotein and RNA dependent RNA transcriptase protein. These proteins play an important role in inducing immune against rabies infection, regulating and transcription, interaction with the cytoplasmic domain of the glycoprotein and the RNP during virus assembly and budding, RNA synthesis and capping respectively. The pathogenesis of rabies virus is unclear, but recent progresses have been made to elucidate these phenomenon. Centripetal spread of the virus to the central nervous system and spread within the central nervous system occur by fast axonal transport. Antibodies induced by vaccination, particularly those with neutralizing activity, play prominent role in immune defense against infection.

Keywords: Encoded protein, Pathogenesis, Rabies virus, Nucleoprotein