February 2018 Vol.6 No.1

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Original Research Article

Role of C-reactive protein in the Assessment of Major Depressive Disorder

Tarun Kanti Paul¹, Shaikh Badiuzzaman², Bibhabari Das³, Sharmeen Ahmed⁴, Mesbah Uddin Ahmed^5* and
Md. Khorshed Alam⁶

¹Lecturer, Department of Microbiology, Sylhet M.A.G. Osmani Medical College, Sylhet
²Junior Consultant, Pathology, 300 Bedded Hospital, Narayanganj
³Medical Officer, Upazila Health Complex, Madhabpur, Habigonj, Sylhet
⁴Lecturer in Microbiology, Anower Khan Modern Medical college, Dhanmondi R/A, Dhaka
⁵MS in Microbiology, Bangladesh University of Health Sciences
⁶Assistant Professor, Department of Pathology, Bashundhara Ad-Din Medical College Hospital, South Keranigonj

*Corresponding Author’s E-mail: mesba.lab@gmail.com

Accepted January 31, 2018

Abstract

Major Depressive Disorder (MDD) is a common psychological problem in the world. In Bangladesh prevalence of MDD is about 4.6%. MDD is associated with reduced quality of life as well as high level of social and occupational impairment. The aim of the study was to investigate the relationship between MDD and inflammation assessed using serum C-reactive protein (CRP). This case control study was conducted at the Department of Laboratory Medicine (Clinical Pathology) in collaboration with the Department of Psychiatry, BSMMU, Dhaka, from March’2016 to February’ 2017. A total of 130 patients were enrolled in this study and divided into Group I (cases) and Group II (controls). Each group was consisted of 65 subjects. The patients who fulfilled the criteria of MDD were determined as cases in this study. This study measured C-reactive protein (CRP) in MDD diagnosed patients and healthy controls. CRP was measured by biochemistry auto analyzer (Dimension RxL Max). The mean age was 33.06±12.23 years for patients with MDD and 33.05±11.43 years for the control group. There was no significant difference between the age for groups (p>0.05). Female [43(66.2%)] were predominant in both groups.CRP levels were found to be 5.25±1.84 mg/L in patients with MDD and 2.56±1.16 mg/L in controls. CRP levels were significantly higher in patients with MDD compared to the control group (p<0.05). In ROC analysis, Cut off value of CRP was (>3.58 mg/L) with sensitivity 83.1% and specificity 72.3%. These findings of the study revealed that CRP trend to be higher in MDD. So this marker may be useful tool for assessing MDD.

Keywords: C-reactive protein, Major depressive disorder, psychological problem, quality of life, Laboratory Medicine