May 2016 Vol.4 No.4

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Original Research Article

Aragonite type of shell powder prepared from the fired Corbiculla japonica shell prevented liver deterioration and lowering lipid level in alcohol-fed mice model

Jin-Ichi Sasaki^1*, Yoshinori Minegishi², Mana Yasui³, Atsushi Yamazaki³ and Changlong Lu⁴

¹Hirosaki University of Health and Welfare, 2-5 Ohgi-machi, Hirosaki 036-8102, Japan
²Aomori Clean-Tech Ltd.2-9-21 Tomita, Aomori 038-0004, Japan
³Department of Resources and Environmental Engineering, Waseda University, 3-4-1 Ohkubo Shinjyuku 169-8555 Tokyo, Japan
⁴Institute of Immunology, China Medical University, 92 North Second Road, Heping District, Shenyang 110001, China

*Corresponding Author’s E-mail: sasakij@jyoto-gakuen.ac.jp

Accepted April 18, 2016

Abstract

Aragonite type of shell powder created by firing bivalve Corbicula japonica shell at 200⁰C for 40min was provided for the bio-activity studies using the alcohol-fed C57BL/6 mice model. Solubility of the aragonite shell powder in 1/10 N acetic acid was 85% and that of non-fired shell powder was 70%. On the test in the alcohol-fed mice model, the aragonite type of shell powder effectively worked to lower AST and ALT values in serum to compare with the values of the saline-fed or just alcohol-fed group. Aragonite shell powder-fed mice lowered level of neutral lipid and cholesterol against control groups in the alcohol-fed mice sera. Aragonite type of shell powder was also functional to protect the alcohol-caused liver deterioration.

Keywords: Alcohol-fed mice model, Aragonite, Corbicula japonica, Lipid value, Liver function