July 2015 Vol.3 No.1

Abstract
• Full text
•Reprint (PDF) (610 KB)

Search Pubmed for articles by:
 

Original Research Article

Colistin-based combination therapy improving Acinetobacter baumannii eradication efficacy

Guoming Su^1,2, Jiamin Wang², Saisai Tang¹, Zuguo Zhao³ and Weiqing Yang^1,2＊

¹Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan, China
²Department of Clinical Microbiology Laboratory, Institute of Medical Laboratory, Guangdong Medical College, Dongguan, China
³Department of Microbiology and Immunology, Guangdong Medical College, Zhanjiang, China

*Corresponding Author's E-mail: yangysu@126.com

Accepted July 13, 2015

Abstract

Acinetobacter baumannii may cause serious infections in critically ill patients. Colistin often remains the only therapeutic option. In this meta-analysis, we aimed to compare the microbiological eradication rate of colistin-based combination therapy with monotherapy in patients with A. baumannii infection. We searched PubMed, Google Scholar and The Cochrane Central Register of Controlled Trials. Data analysis was performed by using Review Manager 5.2 and STATA 12.0 software. A total of seven studies were included in the meta-analysis. Our analysis showed that odds ratio (95% confidence interval (CI)) of overall microbiological eradication was 1.62 (1.16 – 2.27). Results remained robust after sensitivity analysis. The available results suggested that the eradication rate of A. baumannii was relatively higher in the combination therapy group than the monotherapy group.

Keywords: Colistin, Polymyxin, Acinetobacter baumannii, Meta-analysis