January 2014 Vol. 2 No. 1

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Full Length Research Paper

Coagulation Profile (PT, APTT, fibrinogen level and platelets count) in Sudanese patients with acute pancreatitis
 

Sana Eltahir Abdalla¹*, Hana Tajelsir Adam² and Enaam Abdelrahman Abdelgadir³
 

¹AL-Neelain Medical Research Centre. Al-Neelain University. Khartoum- Sudan.
²Medicom Distribution Dubai.
³AL-Neelain University, Faculty of Medicine, Khartoum, Sudan. Pathology Department

*Corresponding Author's E-mail: sanaseed@hotmail.com; Tel 00249912359969; Fax 00249 183 797002

Accepted January 13, 2014
 

Abstract

Pancreatitis is an uncommon disease characterized by inflammation of the pancreas. Acute pancreatitis affects about 50,000–80,000 each year. It is a condition that rises suddenly and may be quite severe, although patients usually have a complete recovery from an acute attack. The aim of this study is to measure the coagulation profile (prothrombin time, activated partial thromboplastin time, platelets counts and fibrinogen level) in Sudanese patients with acute pancreatitis. Fifty blood samples were collected from patients diagnosed as acute pancreatitis cases. Their PT, APTT and fibrinogen were estimated using coagulometer, and platelets were counted using Sysmex™ Kx21n. The mean prothrombin time of the patients’ group was 14.9± 3 sec. while it was 12.6± 1.4 sec in the control group and the mean activated partial thromboplastin time was 40.5±10.7 sec and 34± 1.9 sec in the patients and control groups respectively. The mean fibrinogen concentration in the patients’ group was 246.8± 105.2mg/dl, while it was 267± 52mg/dl in the control group. The mean platelets count was 244.9± 124.4x10⁹/l in patients’ group and 257.7± 55.7x10⁹/dl in control group. This study concluded from this study that prothrombin time and activated partial thromboplastin time were prolonged in acute pancreatitis and fibrinogen level was decreased. Moreover, the platelets counts showed normal values.

Keywords: Prothfombin time, Thromboplastin, Platelets, Fibrinogen.